abstract：:Autophagy as a natural part of cellular homeostasis usually takes place unnoticed by neighboring cells. However, its co-occurrence with cell death may contribute to the clearance of these dying cells by recruited phagocytes. Autophagy associated with programmed cell death has recently been reported to be essential for...

journal_title：Autophagy

authors： Petrovski G,Zahuczky G,Májai G,Fésüs L

更新日期：2007-09-01 00:00:00

abstract：:Survival of environmental stress conditions requires the maintenance of cellular homeostasis. To preserve this balance, cells utilize a degradative mechanism known as autophagy. During this process, in response to starvation or other stresses, bulk cytoplasm is non-specifically sequestered within double-membrane vesic...

journal_title：Autophagy

authors： Legakis JE,Yen WL,Klionsky DJ

更新日期：2007-09-01 00:00:00

abstract：:Macroautophagy ("autophagy") is regulated by the same insulin-amino acid-mTOR signaling pathway that controls protein synthesis. Although the literature does not so far include any direct studies confirming this, we expect autophagy to increase during insulin resistance. We discuss the possibility that this may be a u...

journal_title：Autophagy

authors： Meijer AJ,Codogno P

更新日期：2007-09-01 00:00:00

abstract：:Lysosomal storage diseases (LSDs) are debilitating genetic conditions that frequently manifest as neurodegenerative disorders. They severely affect eye, motor and cognitive functions and, in most cases, abbreviate the lifespan. Postmitotic cells such as neurons and mononuclear phagocytes rich in lysosomes are most oft...

journal_title：Autophagy

authors： Kiselyov K,Jennigs JJ Jr,Rbaibi Y,Chu CT

更新日期：2007-05-01 00:00:00

abstract：:Throughout their life, cells must maintain homeostasis while facing constantly fluctuating demands on their different organelles. A major mechanism for the homeostatic control of organelle function is the unfolded protein response (UPR), a signaling pathway that triggers a comprehensive remodeling of the endoplasmic r...

journal_title：Autophagy

authors： Bernales S,Schuck S,Walter P

更新日期：2007-05-01 00:00:00

abstract：:The 4th International Symposium on Autophagy was held in Mishima, a small town between Tokyo and Kyoto, October 1-5, 2006 (http://isa4th.umin.jp/). The meeting was organized by the group of Eiki Kominami. Approximately 150 participants took part in this well-organized meeting in the spacious and comfortable Toray Conf...

journal_title：Autophagy

authors： Eskelinen EL,Deretic V,Neufeld T,Levine B,Cuervo AM

更新日期：2007-03-01 00:00:00

abstract：:Autophagy has been recently proposed to be a component of the innate cellular immune response against several types of intracellular microorganisms. However, other intracellular bacteria including Listeria monocytogenes have been thought to evade the autophagic cellular surveillance. Here, we show that cellular infect...

journal_title：Autophagy

authors： Py BF,Lipinski MM,Yuan J

更新日期：2007-03-01 00:00:00

abstract：:Autophagy genes were first identified in the yeast system and some of their mammalian orthologues have also been characterized. Increasing lines of evidence indicate that various intracellular proteins, including G proteins, mammalian target of rapamycin (mTor) and Pl3K/Akt/PKB, of transmembrane signaling pathways are...

journal_title：Autophagy

authors： Jia G,Cheng G,Agrawal DK

更新日期：2007-01-01 00:00:00

abstract：:Autophagy is a degradative pathway conserved among eukaryotes. It is a major route for degradation of long-lived proteins and entire organelles, such as peroxisomes. Atg26, a sterol glucosyltransferase, is specifically required for micro- and macropexophagy, but not for starvation-induced bulk autophagy in Pichia past...

journal_title：Autophagy

authors： Cao Y,Klionsky DJ

更新日期：2007-01-01 00:00:00

abstract：:The ubiquitin-like conjugation reactions, ATG8/microtubule-associated protein 1 light chain 3/MAP1LC3 (LC3) to phosphatidylethanolamine (PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades bulk cellular proteins and organelles. The two conjugation reactions share the same E...

journal_title：Autophagy

authors： Shao Y,Gao Z,Feldman T,Jiang X

更新日期：2007-01-01 00:00:00

abstract：:Cytotoxic necrotizing factor 1 is a bacterial protein toxin from Escherichia coli that is able to activate the Rho GTPases and to hinder apoptosis and mitotic catastrophe. Upon exposure to toxin, cells undergo a complex framework of changes, including cytoskeleton remodeling and multinucleation. These cells also show ...

journal_title：Autophagy

authors： Fiorentini C,Malorni W

更新日期：2006-10-01 00:00:00

abstract：:Autophagy is a major pathway for the degradation of long-lived proteins and cytoplasmic organelles and an essential part of programmed cell death, as well. Our findings indicate that programmed cell death of the ovarian follicle cells in the higher Diptera species Bactrocera oleae and Ceratitis capitata manifests feat...

journal_title：Autophagy

authors： Nezis IP,Stravopodis DJ,Margaritis LH,Papassideri IS

更新日期：2006-10-01 00:00:00

abstract：:In the world of pathogen-host cell interactions, the autophagic pathway has been recently described as a component of the innate immune response against intracellular microorganisms. Indeed, some bacterial survival mechanisms are hampered when this process is activated. Mycobacterium tuberculosis infection of macropha...

journal_title：Autophagy

authors： Colombo MI,Gutierrez MG,Romano PS

更新日期：2006-07-01 00:00:00

abstract：:Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of micro...

journal_title：Autophagy

authors： Dubuisson JF,Swanson MS

更新日期：2006-07-01 00:00:00

abstract：:Numerous cardiomyocytes were found to show autophagic vacuolar degeneration in the UM-X7.1 hamster model of human dilated cardiomyopathy, and autophagy-related proteins--i.e., ubiquitin, cathepsin D and Rab7--were upregulated in those hearts. Importantly, Evans blue-positive cardiomyocytes with leaky plasma membranes ...

journal_title：Autophagy

authors： Takemura G,Miyata S,Kawase Y,Okada H,Maruyama R,Fujiwara H

更新日期：2006-07-01 00:00:00

abstract：:The Syrian hamster Harderian gland (HG) is a juxtaorbital organ exhibiting marked gender-associated morphological differences. Regarding contents of porphyrins, this gland is a good model for studying physiological oxidative stress effects, since both sexes present strong (in females) and moderate (in males) levels of...

journal_title：Autophagy

authors： Coto-Montes A,Tomás-Zapico C

更新日期：2006-04-01 00:00:00

abstract：:During reticulocyte maturation, hematopoietic progenitors undergo numerous changes to reach the final functional stage which concludes with the release of reticulocytes and erythrocytes into circulation. During this process some proteins, which are not required in the mature stage, are sequestered in the internal vesi...

journal_title：Autophagy

authors： Fader CM,Colombo MI

更新日期：2006-04-01 00:00:00

abstract：:The induction of autophagy appears to be tightly controlled in all eukaryotic cells. This highly conserved, degradative process is induced by a variety of signals, including nutrient deprivation, and is generally thought to be incompatible with rapid cell growth. Recent work in the budding yeast, Saccharomyces cerevis...

journal_title：Autophagy

authors： Stephan JS,Herman PK

更新日期：2006-04-01 00:00:00

abstract：:The uptake and degradation of cytoplasmic material by vacuolar autophagy in plants has been studied extensively by electron microscopy and shown to be involved in developmental processes such as vacuole formation, deposition of seed storage proteins and senescence, and in the response of plants to nutrient starvation ...

journal_title：Autophagy

authors： Bassham DC,Laporte M,Marty F,Moriyasu Y,Ohsumi Y,Olsen LJ,Yoshimoto K

更新日期：2006-01-01 00:00:00

abstract：:Autophagy is a degradative process conserved among eukaryotic cells. It allows the elimination of cytoplasm including aberrant protein aggregates and damaged organelles. Accordingly, it is implicated in normal developmental processes and also serves a protective role in tumor suppression and elimination of invading pa...

journal_title：Autophagy

authors： Reggiori F,Shintani T,Nair U,Klionsky DJ

更新日期：2005-07-01 00:00:00